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Chris Knobbe, MD on Why Seed Oils are The Single Most Harmful Ingredient in the Human Diet

Dr. Chris Knobbe - Peak Human Podcast


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Chris Knobbe, MD, is a physician, researcher, ophthalmologist, public health advocate, and Associate Clinical Professor Emeritus, formerly of the University of Texas Southwestern Medical Center in Dallas, Texas. Dr. Knobbe is known primarily for his research, publications, and presentations connecting Westernized diets and highly polyunsaturated vegetable oils to numerous chronic diseases, including coronary heart disease, hypertension, stroke, cancers, type 2 diabetes, metabolic syndrome, obesity, Alzheimer’s disease, autoimmune diseases, and age-related macular degeneration (AMD). Dr. Knobbe’s research has focused greatly on the “vegetable oil hypothesis” as the primary driver of overweight and chronic disease. In 2016, Knobbe formally introduced the hypothesis that processed foods and vegetable oils are the primary drivers of AMD, which is the leading cause of irreversible vision loss and blindness in people over the age of 50, worldwide.


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  • (3:06) Dr. Chris Knobbe’s latest publication: Ancestral Diet Revolution

  • (4:54) How Dr. Knobbe left his ophthalmologist practice in 2015 to pursue the topic of seed oils

  • (6:10) The connection between age-related macular degeneration and diet

  • (12:06) Dr. Chris Knobbes impactful use of data and graphs

  • (14:43) Why are seed oils more concerning than other processed foods?

  • (41:31) Dietary changes in populations across the globe and prevalence of disease- the modern displacement of foods

  • (1:04:49) The effect of sugar vs. vegetable oils on the rate of incidence in the United States

  • (1:18:30): Dietary lipid profile is a determinant of tissue phospholipid fatty acid composition and rate of weight gain in rats (DOI: 10.1093/jn/123.3.512)

  • (1:26:40) Seeds oils and poor diet as a driver for cancer

  • (1:34:23) Diet and lifestyle is crucial in determining health outcomes regardless of genetics

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